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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30799
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| 題名: | The liver-protecting activity of melanin-like pigment derived from black tea |
| 作者: | Sava, VM;Hung, YC;Blagodarsky, VA;Hong, MY;Huang, GS |
| 貢獻者: | 藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Acad Sinica, Inst Bot, Dept Biochem, Taipei 115, Taiwan;China Med Coll, Gynecol Oncol Sect, Dept Obstet & Gynecol, Taichung 404, Taiwan;Odessa Reg Psychiat Hosp 1, Odessa, Ukraine |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 15:01:59 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | Previous studies have shown that Disabled-2 (DAB2) is up-regulated during megakaryocytic differentiation of human K562 cells. To delineate the consequences of DAB2 induction, a DNA vector-based small interfering RNA (siRNA) was designed to intervene in DAB2 expression. We found that DAB2 siRNA specifically inhibited DAB2 induction, resulting in the modulation of cell-cell adhesion and mitogen-activated protein kinase (MAPK) phosphorylation. The morphological changes and 03 integrin expression associated with megakaryocytic differentiation were not affected. Since the MAPK pathway has been shown to involve DAB2 induction [Tseng et al., Biochem. Biophys. Res. Commun. 285 (2001) 129-135], our results suggest a reciprocal regulation between DAB2 and MAPK in the differentiation of K562 cells. In addition, we have demonstrated for the first time that DAB2 siRNA is a valuable tool for unveiling the biological consequences of DAB2 expression. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. |
| 關聯: | FOOD RESEARCH INTERNATIONAL 36(5):505-511 |
| 顯示於類別: | [中國藥學研究所(已停用)] 期刊論文
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