Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells

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Title:	Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells
Authors:	Lu, HF;Sue, CC;Yu, CS;Chen, SC;Chen, GW;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Univ, Dept Microbiol, Taichung 400, Taiwan;Cheng Hsin Rehabil Med Ctr, Dept Clin Pathol, Taipei 100, Taiwan;China Med Univ Hosp, Dept Surg, Taichung 400, Taiwan;China Med Univ Hosp, Ctr Gen Educ, Taichung 400, Taiwan
Date:	2004
Issue Date:	2010-09-24 15:01:58 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	Previously, we have screened lactic acid bacteria (LAB) strains from infant feces and evaluated their functional properties. We found a strain of Enterococcus faecium termed as TM39 which is acid and bile tolerant, able to adhere to the intestinal epithelium and with antagonistic activity against Helicobacter pylori. In this study, we demonstrate that strain TM39 is not vancomycin resistant, not invasive to human gastric carcinoma cell line TSGH 9201 and human intestinal epithelial cell line Int-407 in vitro. In addition, we have conducted the in vivo study to evaluate the toxicity of this E faecium strain TM39 in Wistar rats. For such study, cells of strain TM39 were daily oral administrated with dose of 1 x 10(12), 5 x 10(11) and 2 x 10(10) CFU/kg of body weight, respectively, to the rats for 28 consecutive days. There were no adverse effects on the general condition, behavior, growth, feed and water consumption, hematology, clinical chemistry values, organ weights and histopathologic analysis of the rats. Results of this study demonstrate that consumption of strain E faecium TM39, even in large quantities, is not associated with any obvious signs of toxicity in Wistar rats. (C) 2004 Elsevier Ltd. All rights reserved.
Relation:	FOOD AND CHEMICAL TOXICOLOGY 42(10):1543-1552
Appears in Collections:	[School of Medicine] Journal articles

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