Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits

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Title:	Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits
Authors:	Ching, H;Hou, YC;Hsiu, SL;Tsai, SY;Chao, PDL
Contributors:	藥學院中藥所;China Med Coll, Dept Pharm, Taichung 404, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Jen Te Jr Coll Med Nursing & Management, Miaoli, Taiwan
Date:	2002
Issue Date:	2010-09-24 15:01:52 (UTC+8)
Publisher:	PHARMACEUTICAL SOC JAPAN
Abstract:	Bisphosphonates are synthetic pyrophosphate analogs that can be used for the treatment of osteoporosis. Sintered dicalcium pyrophosphate, as a pyrophosphate analog, may be useful in the clinical setting for osteoporosis. In this study, an ovariectornized rat model is used to evaluate the effects of orally administered sintered dicalcium pyrophosphate on bone mass. Thirty-six female rats were used in this study. They randomly were divided into six groups: a negative normal control group, a positive osteoporosis control group, and ovariectomized groups treated either with alendronate sodium (one group) or sintered dicalcium-pyrophosphate (three groups, each at a different level). The animals were sacrificed at 4 weeks after treatment. For all the rats, whole blood samples were obtained for the biochemical study. Bone ashes of long bones were measured and studied and histologic studies of cancellous bone were carried out. The ingestion of either alendronate or sintered dicalcium pyrophosphate did not have any deleterious effect on the major visceral organs. Ingestion of alendronate or sintered pyrophosphate decreased the bony porosity and increased bone mineral contents in the long bones of ovariectomized rats. Thus sintered dicalcium pyrophosphate can increase bone mass in the ovariectomized rat. (C) 2001 John Wiley & Sons, Inc.
Relation:	BIOLOGICAL & PHARMACEUTICAL BULLETIN 25(1):87-91
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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