Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene acompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line

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Title:	Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene acompanying N-acetyltransferase activity and gene expression in human bladder cancer T24 cell line
Authors:	Su, CC;Chen, GW;Yeh, CC;Yang, MD;Hung, CF;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan;China Med Coll, Sch Chinese Med, Taichung 400, Taiwan;China Med Coll Hosp, Dept Surg, Taichung 400, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan
Date:	2003
Issue Date:	2010-09-24 15:01:49 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) expressions as well as Tc-99m methoxisobutylisonitrile (MIBI) images were assessed in 25 patients hepatocellular carcinoma (HCC). Tc-99m MIBI imaging was performed 10 minutes after intravenous injection of 20 mCi Tc-99m MIBI. Using immunohistochemical staining, 60% of the HCC lesions showed positive for Pgp and 64% showed positive for MRP. In 3 patients with MIBI uptake, immunohistochemical study of tumor tissue showed no Pgp stained cells. Nevertheless, they were all positive for MRP. The result of Tc-99m MIBI imaging is more related to the expression of Pgp than MRP gene. It is possible that other membrane transporters as well as Pgp and MRP are involved in the efflux of Tc-99m MIBI. (C) 2003 Elsevier Science Inc. All rights reserved.
Relation:	ANTICANCER RESEARCH 23(1A):355-362
Appears in Collections:	[School of Medicine] Journal articles

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