中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/30785
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    題名: Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats
    作者: Lu, KL;Tsai, CC;Ho, LK;Lin, CC;Chang, YS
    貢獻者: 藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Chung Hwa Inst Technol, Tainan, Taiwan;China Med Coll, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan;Natl Yang Ming Univ, Dept Pharmacol, Taipei, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan
    日期: 2002
    上傳時間: 2010-09-24 15:01:43 (UTC+8)
    出版者: JOHN WILEY & SONS LTD
    摘要: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. In Caucasians, four variant TPMT alleles have been detected in over 80% of individuals with low or intermediate TPMT activity. The wild-type allele is designated as TPMT 1 and the mutant alleles are designated TPMT*2 through TPMT*8. The frequency of these alleles in different ethnic groups has not been well defined. In this study, one hundred individuals, from each of the Indonesian, Thai and Philippine populations, together with 249 Taiwanese, were analysed by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing methods. The results showed that the allelic frequencies of TPMT*3C were 0.6% for Taiwanese and 1% for Filipino, Thai and Indonesian populations, respectively. One Filipino with a Caucasian parent was found to be heterozygous for the TPMT*2 allele. This study provides the first analysis of the allele frequency distribution of all known TPMT mutations in South-east Asian populations. Pharmacogenetics 12:191-195 (C) 2002 Lippincott Williams Wilkins.
    關聯: PHYTOTHERAPY RESEARCH 16():S45-S50
    顯示於類別:[中國藥學研究所(已停用)] 期刊論文

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