Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats

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Title:	Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats
Authors:	Lu, KL;Tsai, CC;Ho, LK;Lin, CC;Chang, YS
Contributors:	藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;Chung Hwa Inst Technol, Tainan, Taiwan;China Med Coll, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan;Natl Yang Ming Univ, Dept Pharmacol, Taipei, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan
Date:	2002
Issue Date:	2010-09-24 15:01:43 (UTC+8)
Publisher:	JOHN WILEY & SONS LTD
Abstract:	Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. In Caucasians, four variant TPMT alleles have been detected in over 80% of individuals with low or intermediate TPMT activity. The wild-type allele is designated as TPMT 1 and the mutant alleles are designated TPMT2 through TPMT8. The frequency of these alleles in different ethnic groups has not been well defined. In this study, one hundred individuals, from each of the Indonesian, Thai and Philippine populations, together with 249 Taiwanese, were analysed by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing methods. The results showed that the allelic frequencies of TPMT3C were 0.6% for Taiwanese and 1% for Filipino, Thai and Indonesian populations, respectively. One Filipino with a Caucasian parent was found to be heterozygous for the TPMT2 allele. This study provides the first analysis of the allele frequency distribution of all known TPMT mutations in South-east Asian populations. Pharmacogenetics 12:191-195 (C) 2002 Lippincott Williams Wilkins.
Relation:	PHYTOTHERAPY RESEARCH 16():S45-S50
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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