HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

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Title:	HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Authors:	Hung, SL;Chung, WH;Liou, LB;Chu, CC;Lin, M;Huang, HP;Lin, YL;Lan, JL;Yang, LC;Hong, HS;Chen, MJ;Lai, PC;Wu, MS;Chu, CY;Wang, KH;Chen, CH;Fann, CSJ;Wu, JY;Chen, YT
Contributors:	附設醫院醫研部;Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan;Chang Gung Mem Hosp, Dept Dermatol, Taipei 10507, Taiwan;Chang Gung Mem Hosp, Dept Rheumatol Allergy & Immunol, Taipei 10507, Taiwan;Chang Gung Mem Hosp, Dept Nephrol, Taipei 10507, Taiwan;Mackay Mem Hosp, Dept Med Res, Taipei 10449, Taiwan;Taichung Vet Gen Hosp, Dept Immunol & Rheumatol, Taichung 40705, Taiwan;Natl Taiwan Univ Hosp, Dept Dermatol, Taipei 10002, Taiwan;Taipei Med Univ Hosp, Dept Dermatol, Taipei 11031, Taiwan;China Med Univ Hosp, Dept Med Res, Taichung 40447, Taiwan;Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA;Acad Sinica, Program Mol Med, Taiwan Int Grad Program, Taipei 11529, Taiwan;Natl Yang Ming Univ, Sch Life Sci, Taipei 11529, Taiwan
Date:	2005
Issue Date:	2010-09-24 15:01:16 (UTC+8)
Publisher:	NATL ACAD SCIENCES
Abstract:	Objective. To investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 polymorphisms in cervical carcinogenesis. Methods. GSTM1, GSTT I and p53 codon 72 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 198 cervical smear samples using multiplex polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism (RFLP) techniques. Results. Forty-two patients with high-grade squamous intraepithelial lesion (HSIL) had higher frequency of high-risk HPV and null GSTT1 genotype than 102 with low-grade SIL (LSIL) and 54 controls. Thirty-one patients with HSIL had also statistically higher frequency of null GSTT1 genotype than 28 with LSIL among 69 patients with high-risk HPV There was no statistical difference in p53 Arg, Arg/pro and Pro genotypes between SILs and controls with or Without high-risk HPV. Conclusion. GSTT1 null genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population. The p53 codon 72 polymorphism is unlikely to be related to HPV status and the onset of cervical cancer. (c) 2004 Elsevier Inc. All rights reserved.
Relation:	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(11):4134-4139
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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