Adventitious shoot regeneration from stem internode explants of Adenophora triphylla (Thunb.) A. DC. (Campanulaceae) - an important medicinal herb

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Title:	Adventitious shoot regeneration from stem internode explants of Adenophora triphylla (Thunb.) A. DC. (Campanulaceae) - an important medicinal herb
Authors:	Chen, CC;Chen, SJ;Sagare, AP;Tsay, HS
Contributors:	藥學院中藥所;Taiwan Agr Res Inst, Dept Agron, Taichung 41301, Taiwan;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 40421, Taiwan
Date:	2001
Issue Date:	2010-09-24 15:00:53 (UTC+8)
Publisher:	ACAD SINICA INST BOTANY
Abstract:	The purpose of this study was to retrospectively predict the chemotherapeutic response to pactitaxel for non-small cell lung cancer (NSCLC) using Tc-99m-tetrofosmin (TF) uptake and to detect the expression of 170-kDa multidrug resistance-mediated P-glycoprotein (MDR-Pgp). Methods: Before chemotherapy with paclitaxel, 20 patients with stage IIIb or IV NSCLC were enrolled in this study to undergo early and delayed Tc-99m-TF chest imaging for calculating tumor-to-normal lung ratios (T/NL) and retention indices (RI) for assessment of the MDR-Pgp in NSCLC. Results: The early and delayed mean T/NLs were 1.59 +/- 0.25 and 1.50 +/- 0,25, respectively, for 10 patients with a good response and 1.09 +/- 0.09 and 1.03 +/- 0.05, respectively for 10 patients with a poor response. The differences were shown to be significant (P < 0.001) by independent Student t tests. However, no significant differences (P = 0.801) between good-response patients (-5,70% +/- 3.67%) and poor-response patients (-5.23% +/- 4,51 %) were found in RI. In addition, other prognostic factors (age, sex, tumor size, stage, and cell type) were not significantly different between good-response patients and poor-response patients. Conclusion: (TC)-T-99m-TF chest images are potential tools for understanding MDR-Pgp expression in NSCLC and for predicting the chemotherapeutic response to paclitaxel.
Relation:	BOTANICAL BULLETIN OF ACADEMIA SINICA 42(1):1-7
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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