Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30737

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题名:	Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome
作者:	Li, YC;Cheng, YM;Hsieh, LJ;Ryder, OA;Yang, F;Liao, SJ;Hsiao, KM;Tsai, FJ;Tsai, CH;Lin, CC
贡献者:	附設醫院醫研部;Lin, CC, China Med Univ & Hosp, Dept Med Res, 2, Yuh Der Rd, Taichung 404, Taiwan
日期:	2005
上传时间:	2010-09-24 15:00:53 (UTC+8)
出版者:	SPRINGER
摘要:	Three flavonoids were isolated from the whole plants of Waltheria indica and biological properties investigated. On the basis of their spectroscopic data, these compounds were identified as (-)-epicatechin, quercetin, and tiliroside. These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-γ activated murine peritoneal macrophages, without displaying cytotoxicity. The order of inhibitory activity was quercetin&GT; tiliroside&GT;(-)-epicatechin. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-γ for 24 h, and the inhibitory effects of the above mentioned isolates on the production of NO were determined after a further 24 h, to address the possible mechanisms of their action. The present study supports the use of W. indica for the treatment of inflammatory diseases in traditional medicine.
關聯:	CHROMOSOMA 114(1):28-38
显示于类别:	[台中附設醫院] 期刊論文

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