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http://ir.cmu.edu.tw/ir/handle/310903500/30736
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| 題名: | Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome |
| 作者: | Li, YC;Cheng, YM;Hsieh, LJ;Ryder, OA;Yang, F;Liao, SJ;Hsiao, KM;Tsai, FJ;Tsai, CH;Lin, CC |
| 貢獻者: | 附設醫院醫研部;Lin, CC, China Med Univ & Hosp, Dept Med Res, 2, Yuh Der Rd, Taichung 404, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:00:52 (UTC+8) |
| 出版者: | SPRINGER |
| 摘要: | Three flavonoids were isolated from the whole plants of Waltheria indica and biological properties investigated. On the basis of their spectroscopic data, these compounds were identified as (-)-epicatechin, quercetin, and tiliroside. These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-γ activated murine peritoneal macrophages, without displaying cytotoxicity. The order of inhibitory activity was quercetin> tiliroside>(-)-epicatechin. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-γ for 24 h, and the inhibitory effects of the above mentioned isolates on the production of NO were determined after a further 24 h, to address the possible mechanisms of their action. The present study supports the use of W. indica for the treatment of inflammatory diseases in traditional medicine. |
| 關聯: | CHROMOSOMA 114(1):28-38 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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