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http://ir.cmu.edu.tw/ir/handle/310903500/30732
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| 題名: | Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan |
| 作者: | Lin, YC;Chang, YM;Yu, JM;Yen, JH;Chang, JG;Hu, CJ |
| 貢獻者: | 附設醫院醫研部;Taipei Municipal Jen Ai Hosp, Dept Neurol, Taipei 106, Taiwan;Taipei Municipal Jen Ai Hosp, Mol Med Lab, Taipei 106, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Rheumatol, Kaohsiung, Taiwan;China Med Univ Hosp, Dept Med Res & Clin Pathol, Taichung, Taiwan;Taipei Med Univ, Brain Dis & Aging Res Ctr, Taipei, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:00:48 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | The doses of hepatitis B vaccine given to peritoneal dialysis (PD) patients are currently based on responsiveness data from hemodialysis (HD) patients. To determine whether the doses are also appropriate from PD patients, we did a head-to-head comparison of short-term and 2-year responses to hepatitis B vaccination of HD patients and PD patients. We evaluated serum titers of the antibody to hepatitis B surface antigen (anti-HBs) after the patients had completed a course of four consecutive intramuscular vaccinations (40 mu g of Engerix-B administered into the deltoid muscle at 0, 1, 2, and 6 months) in 69 dialysis patients (47 HD and 22 PD patients) who were both hepatitis B surface antigen (HBsAg) and anti-HBs negative. No patients had received a hepatitis B vaccination prior to the study. There was no significant difference in response to hepatitis B vaccination between the HD and PD groups (78.7% versus 77.3%, p = 0.33). The seroconversion rate defined as anti-HBs >= 10 IU/L was influenced only by age (p = 0.011). There was also no significant difference in responsiveness between the HD and PD groups (60% versus 50%, p = 0.41) at a 2-year follow-up. We conclude that doses of HBV vaccine being used for HD patients are also appropriate for PD patients and a booster dose of vaccine is required to maintain seroprotection for those who lost protecting anti-HBs. (c) 2005 Elsevier Ltd. All rights reserved. |
| 關聯: | ATHEROSCLEROSIS 180(2):305-309 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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