Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells

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Title:	Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells
Authors:	Li, YC;Hung, CF;Yeh, FT;Lin, JP;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan;China Med Coll, Sch Chinese Med, Taichung 400, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 400, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan;Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung 400, Taiwan
Date:	2001
Issue Date:	2010-09-24 15:00:41 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	In this study, we examined the effects of natural humic acid (HA) purified from drinking well-water in Blackfoot disease (BFD) endemic areas, using synthetic humic acid (SHA), such as protocatechuic acid, ferulic acid, vanillic acid or catechol, and trivalent arsenic on human plasmin activity. Data in this report indicated that both HA and SHA inhibited human plasmin activity by 20-80 and 5-95%, respectively, at concentrations of 20-480 mug/ml. Organometallic complexes composed of HA and arsenic show enhanced inhibition of plasmin activity as compared with either HA or arsenic alone. Monomers of HA or arsenic alone do not inhibit plasma activity. Oxidative stress may play a role in the inhibition of plasma activity, as various fret-radical scavengers, such as ascorbic acid, ol-tocopherol, catalase and superoxide dismutase (SOD), abrogate the inhibitory effects of HA and HA-arsenic complexes. The notion that HA/organometallic complexes (HA/OR) impaired plasmin activity was significant, due to the fact that both of these agents (HA and arsenic) are etiological factors in the development of peripheral vascular diseases, such as BFD. This report substantiates the inhibitory effects of HA/OR on plasmin activity, and thus provides evidence for the partial mechanism of action of HA/OR in BFD. (C) 2001 Elsevier Science B.V. All rights reserved.
Relation:	FOOD AND CHEMICAL TOXICOLOGY 39(7):641-647
Appears in Collections:	[School of Medicine] Journal articles

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