Comparison of pharmacokinetics between glycyrrhizin and glycyrrhetic acid in rabbits

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Title:	Comparison of pharmacokinetics between glycyrrhizin and glycyrrhetic acid in rabbits
Authors:	Ching, H;Hsiu, SL;Hou, YC;Chen, CC;Chao, PDL
Contributors:	藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;China Med Coll, Dept Pharm, Taichung 404, Taiwan
Date:	2001
Issue Date:	2010-09-24 15:00:37 (UTC+8)
Publisher:	NATL LABORATORIES FOODS DRUGS
Abstract:	p21, an important regulator of the cell cycle, acts as a mediator of the growth-suppressing and -promoting functions of p53. We aimed to investigate the association between codon 31 polymorphisms of p21 gene and endometriosis. Women were divided into two groups: endometriosis (n = 102) and nonendometriosis (n = 119). The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg). Polymorphisms (Ser homozygotes, heterozygotes, Arg homozygotes) between both groups were detected and compared. Associations between the endometriosis and polymorphisms were evaluated. The results revealed that the distributions of different p21 polymorphisms in both groups were nonsignificantly different. The proportions of Ser homozygote/heterozygote/Arg homozygote in endometriosis and non-endometriois populations were 26.5/48.0/25.5% and 17.6/50.4/31.9%, respectively. We concluded the noncorrelation between the endometriosis and the p21 codon 31 polymorphism. p21 gene codon 31 arginine/serine polymorphism is not a useful marker for prediction of endometriosis susceptibility. (C) 2001 Wiley-Liss, Inc.
Relation:	JOURNAL OF FOOD AND DRUG ANALYSIS 9(2):67-71
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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