Effects of the immunomodulator tilorone on the acetylation of 2-aminofluorene and DNA-2-aminofluorene adducts in the rats

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题名:	Effects of the immunomodulator tilorone on the acetylation of 2-aminofluorene and DNA-2-aminofluorene adducts in the rats
作者:	Chung, JG;Chang, HL;Yeh, CC;Lu, HF;Chang, CC;Tsai, HD
贡献者:	醫學院醫學系微生物學科;China Med Coll, Dept Med, Dept Microbiol, Taichung 400, Taiwan;China Med Coll, Dept Pharmacol, Taichung 400, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 400, Taiwan
日期:	2000
上传时间:	2010-09-24 15:00:15 (UTC+8)
出版者:	INT INST ANTICANCER RESEARCH
摘要:	Anemia is generally attributed to zidovudine therapy in human immunodeficiency virus (HlV)-infected patients, although parvovirus B19 infection has been reported as a rare cause. We report on a 24-year-old homosexual man infected with HIV who presented with anemia. He had received aggressive daily antiretroviral therapy (zidovudine 600 mg, lamivudine 300 mg, and saquinavir 1,800 mg) for 2 years. At the time of admission, his CD4+ count was 10 x 10(6) cells/L. A bone marrow aspirate smear showed a marked decrease in erythropoiesis and immunocytochemical staining for parvovirus B19 was positive. Parvovirus B19 viral DNA was detected in the peripheral blood using a polymerase chain reaction-based assay. Serologic studies were positive for parvovirus B19 immunoglobulin (Ig)M antibodies, but negative for IgG antibodies. The patient was treated with packed red blood cell transfusion. Zidovudine was stopped and replaced with zalcitibine 2.25 mg daily after anemia occurred. He did not receive intravenous Ig therapy because of its cost. After discontinuation of zidovudine for 1 year, anemia persisted and the patient depended on regular blood transfusions to control the anemia. This case emphasizes that, in addition to drug-related causes, parvovirus B19 infection should be inducted in the differential diagnosis of chronic anemia in HIV-infected individuals.
關聯:	ANTICANCER RESEARCH 20(1A):467-473
显示于类别:	[醫學系] 期刊論文

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