Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety

CMUR > College of Pharmacy > Graduate Institute of Chinese Pharmaceutical Science > Journal articles > Item 310903500/30684

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Title:	Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety
Authors:	Peng, WH;Hsieh, MT;Lee, YS;Lin, YC;Liao, J
Contributors:	藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung, Taiwan;Taichung Municipal Jen Ai Hosp, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:59:58 (UTC+8)
Publisher:	ELSEVIER SCI LTD
Abstract:	Cytokines produced by macrophages in the periprosthetic membranes surrounding joint replacements have been implicated as causal agents in osteolysis and prosthetic loosening. The present study characterizes the response of human peripheral blood monocytes to titanium particles. Monocytes were obtained from donated blood and were cultured in the presence of different-sized titanium particles. Exposure to tiranium-aluminum-vanadium particles significantly changed the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1), whereas there was no significant effect on the release of prostaglandin E-2 (PGE(2)). When monocytes were cultured with par ticles, the titanium alloy particles induced significantly more release of TNF-alpha and less IL-1 secretion. Ciprofloxacin inhibited production of TNF-alpha, IL-6, IL-1, and PGE(2) in human monocytes exposed to titanium particles. In contrast to ciprofloxacin, indomethacin was not a potent inhibitor of TNF-alpha production but potentiated IL-6 production in titanium-stimulated monocytes. Indomethacin had no effect on the production of IL-1 and was a potent inhibitor of PGE(2) production in titanium-stimulated monocytes. Pentoxifylline had an inhibitor effect on TNF-alpha production in titanium-stimulated monocytes. Pentoxifylline potentiated IL-6 and IL-1 production in monocytes exposed to titanium particles and had a biphasic effect on the PGE(2) production. The results of this study support our hypothesis that human monocytes release bone resorption mediators after in vitro exposure to TiAlV alloy particles. The results also demonstrate the differences of bone-resorbing mediators in response to different wear particle size. The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes. The results help to elucidate the differences in cellular response to wear particles but may not be directly transposed to the human situation. (C) 2000 John Wiley & Sons, Inc.
Relation:	JOURNAL OF ETHNOPHARMACOLOGY 72(3):435-441
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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