Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30668

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题名:	Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer
作者:	Lin, SY;Yeh, KT;Chen, WTL;Chen, HC;Chen, ST;Chang, JG
贡献者:	附設醫院醫研部;China Med Univ Hosp, Dept Mol Med, Taichung, Taiwan;Taipei Med Univ Hosp, Dept Internal Med, Taipei, Taiwan;Taipei Med Univ, Dept Internal Med, Sch Med, Taipei, Taiwan;Chang Hua Christian Hosp, Dept Surg, Div Proctol, Changhua, Taiwan;Chang Hua Christian Hosp, Dept Pathol, Changhua, Taiwan
日期:	2004
上传时间:	2010-09-24 14:59:42 (UTC+8)
出版者:	INT INST ANTICANCER RESEARCH
摘要:	Many arylamines (including carcinogens) and hydrazine drugs are acetylated by the cytosolic N-acetyltransferase (NAT). NAT plays an important role in the first step of arylamine metabolism and has been found in immortalized human cell lines, human and laboratory animal tissues. Human colon tumor cell line (colo 205) has also been shown to acetylate arylamine and possess NAT activity. The purpose of this study was to determine whether or not N-ethylphenyl acetamide (EPA) could affect cell viability, DNA synthesis and N-acetylation of 2-aminofluorene (AF) in colo 205 cells. Acetylated and nonacetylated AF were determined by using high performance liquid chromatography. EPA displayed a dose-dependent inhibition of cytosolic and intact cells' NAT activity, inhibition of viablility and DNA synthesis. Time-course experiments showed that N-acetylation of AF measured from intact colo 205 cells was inhibited by EPA for up to 48 h.
關聯:	ANTICANCER RESEARCH 24(3A):1645-1650
显示于类别:	[台中附設醫院] 期刊論文

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