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http://ir.cmu.edu.tw/ir/handle/310903500/30657
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| 題名: | Effects of aspirin on arylamine N-acetyltransferase activity and DNA adducts in human bladder tumour cells |
| 作者: | Yeh, CC;Chung, JG;Wu, HC;Chang, HL;Yeh, FT;Hung, CF |
| 貢獻者: | 醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;China Med Coll, Dept Pharmacol, Taichung 400, Taiwan;China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 400, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Surg, Taichung, Taiwan |
| 日期: | 1999 |
| 上傳時間: | 2010-09-24 14:59:29 (UTC+8) |
| 出版者: | JOHN WILEY & SONS LTD |
| 摘要: | In this study, we investigated the effects of Pai-Hui by acupuncture on cycloheximide (CXM)-induced impairment of the passive avoidance response in rats. Acupuncture at Pai-Hui (Go-20) treated 15 min before or immediately after training trial for 15 min significantly attenuated CXM-induced impairment of passive avoidance response in rats, but did not have the same effect 30 and 60 min before or 30 min after the training trial or before the retention trial. Acupuncture at Pai-Hui 15 min before the training trial for 15, 30 and 60 min significantly attenuated CXM-induced impairment of passive avoidance response in rats, and its efficacy paralleled the acupuncture duration. Furthermore, acupuncture at Pai-Hui did not attenuate scopolamine (SCOP)-induced impairment of passive avoidance response, but was slightly inhibited by SCOP at 0.3 mg/kg. Second, acupuncture at Pai-Hui attenuated p-chloroamphetamine (PCA)-induced impairment of passive avoidance response and was significantly antagonized by PCA at 1 mg/kg. These results suggest that acupuncture at Pai-Hui mainly affects the memory storage process and has preventive and immediate therapeutic effects on CXM-induced impairment of passive avoidance response. Its efficacy paralleled the acupuncture duration. The preventive effect of acupuncture at Pai-Hui on CXM-induced impairment is significantly reduced by serotonergic 5-HT releaser, and slightly by cholinergic manipulations. |
| 關聯: | JOURNAL OF APPLIED TOXICOLOGY 19(6):389-394 |
| 顯示於類別: | [醫學系] 期刊論文
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