Effects of sulindac on arylamine N-acetyltransferase activity in human colon tumour cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 期刊論文 > Item 310903500/30648

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题名:	Effects of sulindac on arylamine N-acetyltransferase activity in human colon tumour cells
作者:	Chang, SH;Chung, JG;Wu, LT;Huang, LJ;Chen, SC;Kuo, SC
贡献者:	醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan
日期:	1998
上传时间:	2010-09-24 14:59:21 (UTC+8)
出版者:	FACULTY PRESS
摘要:	Paeonol was used to determine effects of arylamine N-acetyltransferase (NAT) activity in a rat liver tumour cell line. The NAT activity was measured by high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (2-AAF), N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and the remaining a-aminofluorene (2-AF) and p-aminobenzoic acid (PABA). The NAT activity in liver tumour cell cytosols and intact tumour cells was increased by paeonol in a dose-dependent manner. The apparent values of K-m and V-max also increased after co-treatment of paeonol in both tissues. This report is the first to show that paeonol promoted rat liver tumour cell NAT activity.
關聯:	CYTOBIOS 95(378):25-36
显示于类别:	[醫學系] 期刊論文

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