The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease

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Title:	The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease
Authors:	Liu, HC;Leu, SJ;Chang, JG;Sung, SM;Hsu, WC;Lee, LS;Hu, CJ
Contributors:	附設醫院醫研部;Taipei Municipal Jen Ai Hosp, Dept Neurol, Taipei, Taiwan;Taipei City Psychiat Ctr, Dept Neurol & Psychiat, Taipei, Taiwan;Taipei Med Univ, Grad Inst Cell & Mol Biol, Taipei, Taiwan;China Med Coll Hosp, Dept Med Res, Div Mol Med, Taichung, Taiwan;Tapei Municipal Jen Ai Hosp, Mol Med Lab, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:59:01 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Objectives. To compare control women with men and women with type 2 diabetes mellitus (DM) for the prevalence and type of renal damage due to urinary tract infections (UTIs) using technetium-99m dimercapto-succinic acid (Tc-99m DMSA) renal scanning. Women with DM have UTIs more often than do women without DM. It is unknown, however, what the prevalence and type of renal damage due to UTI are in these women. Methods. Three groups of patients: 28 control women without type 2 DM and a history of UTIs, 25 male patients with type 2 DM but without a history of UTIs, and 103 female patients with type 2 DM underwent Tc-99m DMSA renal scan. The 103 women with type 2 DM were separated into three groups: 36 women without a history of UTIs, 34 patients with a history of cystitis only, and 33 with a history of pyelonephritis. Results. All the control women and male patients with type 2 DM without a history of UTIs had normal Tc-99m DMSA renal scan findings. However, 39.8% of women with type 2 DIM had abnormal Tc-99m DMSA renal scan findings. Women with type 2 DM without a history of UTI had a significantly lower prevalence of abnormal renal scan findings than did those with a history of cystitis only or pyelonephritis. In addition, the prevalence of abnormal renal scan findings was significantly higher in women with type 2 DM with pyelonephritis than in those with a history of cystitis only. Renal scars on Tc-99m DMSA renal scans were found in women with type 2 DM and a history of pyelonephritis. Conclusions. Compared with control women and men with type 2 DM, women with type 2 DM, especially if they had a history of UTIs, had a significantly higher prevalence of abnormal Tc-99m DMSA renal scan findings.
Relation:	BRAIN RESEARCH 961(1):88-91
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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