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http://ir.cmu.edu.tw/ir/handle/310903500/30627
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| 題名: | Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: Interactions with compounds acting at 5-HT1A and 5-HT2 receptors |
| 作者: | Hsieh, MT;Wu, CR;Hsieh, CC |
| 貢獻者: | 藥學院中藥所;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung, Taiwan;Vet Gen Hosp, Dept Pediat, Taipei, Taiwan |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 14:58:56 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | The effects of dietary monounsaturated fatty acid (MUFA) and polyunsaturated: fatty acid + MUFA/saturated fatty acid (PUFA + MUFA/SFA) ratio on plasma and liver lipid concentrations were studied. In experiment I, when rats were fed with 40% fat (energy%, PUFA/SFA ratio 1.0) and 1% (w/w) cholesterol (C) diets for 21 d, a large amount of MUFA (28.1 energy%, PUFA + MUFA/SFA = 5.7) in the diet was found to increase the plasma total C, triacylglycerol (TAG), and phospholipid (PL) as compared with the low-MUFA diet (7.0 energy%, PUFA + MUFA/SFA = 1.4). The plasma very low density lipoprotein (VLDL)-C, VLDL-TAG, VLDL-PL, and low density lipoprotein (LDL)-C increased significantly in the high-MUFA diet group, but high density lipoprotein (HDL)-C did not change significantly. The high-MUFA diet resulted in greater accumulation of liver C but lesser accumulation of TAG. In experiment II, when dietary SFA was fixed at a certain level (13.2 energy%; PUFA + MUFA/SFA = 2.0), rats given a larger amount of MUFA (23.1 energy%; PUFA/MUFA = 0.2; MUFA/SFA = 1.8) showed higher plasma and liver C levels than did the low-MUFA diet (7.7 energy%; PUFA/MUFA = 2.5; MUFA/SFA = 0.6). When PUFA was fixed at a certain level (24.4 energy%), there was not a significant difference in the plasma C level between the high- and low-MUFA dietary groups (PUFA + MUFA/SFA = 4.8 and 8.4), but the higher PUFA + MUFA/SFA diet, which was high in MUFA/SFA ratio, significantly decreased the plasma HDL-C and TAG levels. However, when MUFA content was fixed at a certain level (16.4 energy%), no significant difference was observed between the two groups with different PUFA/SFA ratios of 0.2 and 4.1, but liver C level was raised in the higher PUFA/SFA diet. It appears that the PUFA/SFA ratio alone is unsuitable to predict the change of plasma C level, because a large amount of dietary MUFA may lead to an increase of plasma and liver lipids in rats. It seems that the prerequisites for keeping low plasma and liver C are (i) low MUFA/SFA ratio, (ii) high PUFA/MUFA ratio, and (iii) PUFA + MUFA/SFA ratio not to exceed 2. |
| 關聯: | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 60(2):337-343 |
| 顯示於類別: | [中國藥學研究所(已停用)] 期刊論文
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