Detection of recurrent nasopharyngeal carcinomas with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy

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Title:	Detection of recurrent nasopharyngeal carcinomas with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy
Authors:	Tsai, MH;Lin, CC;Shiau, YC;Lee, CC;Tai, CJ;Kao, A
Contributors:	附設醫院醫研部;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Otolaryngol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Taipei 10764, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:58:42 (UTC+8)
Publisher:	ANNALS PUBL CO
Abstract:	Vascular endothelial growth factor (VEGF) functions as a regulator of neovascularization in malignant cells. VEGF as a mitogen is thought to alter renal cell carcinoma formation and tumor progression. We investigated the expression of the VEGF gene in order to evaluate its clinical significance in renal cell carcinoma. Tissue samples from 198 patients with renal cell carcinoma were examined with an immunohistochemical stain for the expression of the VEGF gene. The expression rate was compared to 34 normal renal cortical samples obtained from renal surgery from noncancer patients. There were significant differences between normal renal cortex (0%) and cancer tissue (54.5%) in positive staining of VEGF protein (P<0.001). With the progression of tumor grade, the positive rate of VEGF gene expression significantly increased. The expression rate of the VEGF gene in the advanced group, such as with lymph node involvement or vein invasion, was greater than that in the locally confined group (P<0.001). The results revealed that expression of the VEGF gene is proportional to the formation and progression of renal cell carcinoma, which may allow VEGF to be used as a prognostic marker for renal cell carcinoma. (C) 2003 Wiley-Liss, Inc.
Relation:	ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 112(5):415-418
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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