中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/30612
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    题名: Glutathione-S-trans ferase and p53 polymorphisms in cervical carcinogenesis
    作者: Ueda, M;Hung, YC;Terai, Y;Saito, J;Nunobiki, O;Noda, S;Ueki, M
    贡献者: 醫學院醫學系婦產部;Osaka Med Coll, Dept Obstet & Gynecol, Takatsuki, Osaka 5698686, Japan;China Med Coll, Dept Obstet & Gynecol, Taichung, Taiwan;Kansai Med Coll, Dept Obstet & Gynecol, Osaka, Japan;Osaka Canc Prevent Ctr, Osaka, Japan
    日期: 2005
    上传时间: 2010-09-24 14:58:41 (UTC+8)
    出版者: ACADEMIC PRESS INC ELSEVIER SCIENCE
    摘要: Objective. The purpose of this study was to examine whether interleukin-1 receptor antagonist (IL-1Ra) gene polymorphism is a marker of susceptibility to or of the clinical characteristics of gout in Taiwanese patients. Methods. 196 Taiwanese patients with gout and 103 unrelated normal healthy control subjects living in central Taiwan were studied. Polymorphism of the gene for IL-1Ra was typed from genomic DNA. Allelic frequencies and carriage rates were compared between gout patients and control subjects. The relationship between IL-1Ra genotypes and the clinical characteristics of gout was also evaluated. Results. No significant differences were observed in genetic and allelic frequencies of the IL-1Ra gene polymorphism between patients with gout and healthy control subjects. Furthermore, we did not detect any association of IL-1Ra genotype with the clinical and laboratory profiles in patients with gout. Conclusion. The results from the present study suggest that the interleukin-1 receptor antagonist gene polymorphism is not a genetic marker of susceptibility to gout for Taiwanese. Furthermore, our study also suggests that the IL-1Ra gene polymorphism is unrelated to the clinical characteristics of gout.
    關聯: GYNECOLOGIC ONCOLOGY 96(3):736-740
    显示于类别:[醫學系] 期刊論文

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