Effect of long-term administration of berberine on scopolamine-induced amnesia in rats

CMUR > College of Pharmacy > Graduate Institute of Chinese Pharmaceutical Science > Journal articles > Item 310903500/30607

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Title:	Effect of long-term administration of berberine on scopolamine-induced amnesia in rats
Authors:	Peng, WH;Hsieh, MT;Wu, CR
Contributors:	藥學院中藥所;Peng, WH, CHINA MED COLL,INST CHINESE PHARMACEUT SCI,91 HSUEH SHIH RD,TAICHUNG,TAIWAN
Date:	1997
Issue Date:	2010-09-24 14:58:36 (UTC+8)
Publisher:	JAPANESE PHARMACOLOGICAL SOC
Abstract:	Technetium-99m-tetrofosmin has emerged as a new radiopharmaceutical for myocardial imaging, in competition with Tl-201 and Tc-99m-MlBI. In this study, Tc-99m-tetrofosmin was evaluated for its ability to detect malignant and benign lesions from single solid lung masses. Methods: Forty-nine patients with a single solid lung mass based on chest radiograph findings received Tc-99m-tetrofosmin SPECT of the chest to evaluate the value of Tc-99m-tetrofosmin SPECT for detecting malignant and benign lesions. Results: Only 61% of the lung malignancies were detected by Tc-99m-tetrofosmin SPECT of the chest, including 53% of epidermoid carcinoma (ca), 67% of adeno ca, 75% of small-cell ca, 0% of undifferentiated large-cell ca and 100% of other lung malignancies. In addition, 50% of the benign lesions were detected by chest Tc-99m-tetrofosmin SPECT. The probability of tetrofosmin uptake in the mass was not related to mass size. The diagnostic sensitivity, specificity and accuracy were 61%, 50% and 59%, respectively, for differentiating malignant and benign lesions when diagnosing a single solid lung mass. Conclusion: Technetium-99m-tetrofosmin SPECT of the chest is of little or no value for the detection of lung ca from single solid lung masses.
Relation:	JAPANESE JOURNAL OF PHARMACOLOGY 74(3):261-266
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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