Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes

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Title:	Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes
Authors:	Jou, MJ;Peng, TI;Reiter, RJ;Jou, SB;Wu, HY;Wen, ST
Contributors:	醫學院醫學系神經學科;Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan, Taiwan;Chang Gung Mem Hosp, Lin Kou Med Ctr, Dept Neurol, Tao Yuan, Taiwan;Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA;China Med Univ, Dept Neurol, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:58:28 (UTC+8)
Publisher:	BLACKWELL MUNKSGAARD
Abstract:	In this study, we employed techmium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan to detect subclinical lung injury of patients with noninsulin-dependent diabetes mellitus (NIDDM) who had normal chest X-ray findings (CXR) and pulmonary function test (PFT). The degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratios) calculated by Tc-99m HMPAO lung scan. The L/L ratios of the 20 male NIDDM patients with normal CXR and PFT were compared with those of the 20 male normal controls. The results show that the L/L ratios on Tc-99m HMPAO lung scan were significantly higher in NIDDM patients than those in normal controls. Using a cutoff value of 0.50, 17 of the 20 (85%) NIDDM patients had abnormally increased L/L ratios. Our findings concluded that the pulmonary vascular endothelium damage represented as significantly increased L/L ratios on Tc-99m HMPAO lung scan in NIDDM patients with normal CXR and PFT. In addition, Tc-99m HMPAO lung scan has the potential to be a sensitive, objective, and noninvasive method to detect subclinical lung injury of patients with NIDDN, which are different from the traditional studies such as CXR or CFT. (C) 2004 Elsevier Inc. All rights reserved.
Relation:	JOURNAL OF PINEAL RESEARCH 37(1):55-70
Appears in Collections:	[School of Medicine] Journal articles

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