中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/30587
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    题名: Changes of superoxide dismutase (SOD) mRNA and activity in response to hypoxic stress in cultured Wistar rat glioma cells
    作者: Chang, CK;Tsai, CY;Lin, LS;Jou, SB;Liao, SS;Cheng, JT
    贡献者: 醫學院醫學系神經學科;NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL,TAINAN 70101,TAIWAN;MACKAY MEM HOSP,DEPT SURG,DIV NEUROSURG,TAIPEI 10401,TAIWAN;CHINA MED COLL,DEPT NEUROL,TAICHUNG 40408,TAIWAN
    日期: 1997
    上传时间: 2010-09-24 14:58:15 (UTC+8)
    出版者: ELSEVIER SCI IRELAND LTD
    摘要: In this study, we attemped to identify the interactions and mechanisms between veratrine and paeoniflorin on isolated rat atria. Paeoniflorin alone showed no effect on the rat atria. Veratrine increased the atrial contraction and induced arrhythmia at 1 x 10(-5) g/ml. Veratrine could directly induce contraction and elicit tetanic contraction at 1 x 10(-4) g/ml in the left atria with or without electric stimulation. Paeoniflorin (4.8 x 10(-6) to 4.8 x 10(-3) g/ml), verapamil (2.2 x 10(-6) g/ml), tetrodotoxin (TTX) (3.2 x 10(-8) g/ml) and quinidine (7.5 x 10(-6) g/ml) inhibited the increase of contraction and delayed the onset of contraction induced by veratrine (1 x 10(-5) g/ml). The inhibitory effect of paeoniflorin combined with verapamil on the contraction induced by veratrine was more potent than that of paeoniflorin or verapamil alone, However, the inhibitory effect of paeoniflorin was not potentiated by TTX or quinidine. From the above results, the contraction evoked by veratrine in the rat atria may be concluded to be caused by the stimulation of Na+- and Ca2+-ion channels. The inhibition of paeoniflorin on the contraction induced by veratrine may primarily be related to the blockade of Ca2+ channels. (C) 1997 Elsevier Science Ireland Ltd.
    關聯: NEUROSCIENCE LETTERS 232(2):115-118
    显示于类别:[醫學系] 期刊論文

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