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http://ir.cmu.edu.tw/ir/handle/310903500/30581
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| 題名: | Changes of neuropeptide Y messenger RNA and peptide by drugs influencing endogenous norepinephrine content in cerebrocortex of the rat |
| 作者: | Niu, CS;Chang, TK;Cheng, JT |
| 貢獻者: | 醫學院醫學系神經學科;NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL,TAINAN 70101,TAIWAN;CHINA MED COLL,DEPT NEUROL,TAICHUNG,TAIWAN |
| 日期: | 1996 |
| 上傳時間: | 2010-09-24 14:58:08 (UTC+8) |
| 出版者: | LIPPINCOTT-RAVEN PUBL |
| 摘要: | As part of our continuing search for potential anticancer drug candidates that are selective against slowly growing solid tumors, we have synthesized several series of 1- and a-substituted derivatives of the lead structure, 1-ethyl-2-methylnaphth[2,3-d]imidazole-4,9-dione (5). Their cytotoxic activity in the National Cancer Institute's in vitro cancer cell line panel is reported. In general, substitution of various alkyl, phenyl, or benzyl moieties did not improve activity, and compound 5 remains the most active naphth[2,3-d]imidazole-4,9-dione derivative. However, high levels of activity and selectivity were found with several related 2-(acylamino)-3-chloro-1,4-naphthoquinone, (2f-j). Compound 2i, 2-[(2-fluorophenyl)acetamido]-3-chloro-1,4-naphthoquinone, has been selected for further in vivo testing and as an additional lead compound for further structural modification. |
| 關聯: | JOURNAL OF NEUROCHEMISTRY 66(5):2100-2104 |
| 顯示於類別: | [醫學系] 期刊論文
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