To predict response chemotherapy using technetium-99m tetrofosmin chest images in patients with untreated small cell lung cancer and compare with p-glycoprotein, multidrug resistance related protein-1, and lung resistance-related protein expression

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Title:	To predict response chemotherapy using technetium-99m tetrofosmin chest images in patients with untreated small cell lung cancer and compare with p-glycoprotein, multidrug resistance related protein-1, and lung resistance-related protein expression
Authors:	Kuo, TH;Liu, FY;Chuang, CY;Wu, HS;Wang, JJ;Kao, A
Contributors:	附設醫院醫研部;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;Show Chwan Mem Hosp, Div Chest Med, Dept Internal Med, Changhua, Taiwan;Show Chwan Mem Hosp, Div Chest Surg, Changhua, Taiwan;Show Chwan Mem Hosp, Dept Surg, Changhua, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:57:46 (UTC+8)
Publisher:	ELSEVIER SCIENCE INC
Abstract:	To investigate the prevalence and genetic characteristics of myotonic dystrophy type 1 (DM1) in Taiwan, DM-suspected patients and their families identified during the period of 1990-2001 had their clinical records re-evaluated and the CTG repeat sizes at the DM1 locus examined. A total of 96 subjects belonging to 26 families were identified as DM1 patients, which gave a minimal disease prevalence of 0.46/100,000 inhabitants. Clinical anticipation was frequently observed in affected families, even in some parent-child pairs with transmission contraction of the CTG repeat size. The inverse correlation between age at onset and CTG repeat length was significant only in patients with small expansions. In addition, a DM1 carrier with a childhood-onset son was found to have CTG length heterogeneity in the range of 40-50, indicating that premutation alleles could be unstable during gametogenesis as well as in somatic tissues. Our data demonstrated that DM1 is a rare disease in Taiwan and showed that transmission contraction of repeat size is more likely to occur in alleles with large repeats. Copyright (C) 2003 S. Karger AG, Basel.
Relation:	NUCLEAR MEDICINE AND BIOLOGY 30(6):627-632
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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