Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30549

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题名:	Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer
作者:	Yeh, KT;Chang, JG;Lin, TH;Wang, YF;Chang, JY;Shih, MC;Lin, CC
贡献者:	附設醫院醫研部;China Med Coll Hosp, Dept Mol Med, Taichung, Taiwan;China Med Coll Hosp, Dept Lab Med, Taichung, Taiwan;Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan
日期:	2003
上传时间:	2010-09-24 14:57:32 (UTC+8)
出版者:	PROFESSOR D A SPANDIDOS
摘要:	Human platelet antigen (HPA) systems consist of more than twelve bi-allelic antigen polymorphisms in which a base pair substitution leads to change in an amino acid of a glycoprotein expressed on the platelet. The neonatal alloimmune thrombocytopenia (NAIT), post transfusion purpura, and refactoriness to platelet transfusion can be induced by antibodies against human platelet antigens: e.g. HPA-1a, 3a, 4a, 5a, and Gov(a). HPA typing is essential for the diagnosis and treatment of a variety of diseases. We developed a PCR-based method to detect HPA-1 to HPA-13, Oe and Gov platelet alloantigens. In this method, the amplified PCR products were used to recognize the polymorphism after restriction enzyme digestions. Among 566 Taiwanese, 107 Indonesian, 100 Filipino and 137 Thai subjects studied, HPA-1 a, 2a, 4a, 5a, 6a, 7aW, 8aW, 9a, 10a, I I a, 12a, 13a, Oe a genes were present in every sample; while HPA-1b, 2b, 4b, 5b and 6b were rarely found. HPA-7aW, 8aW, 9, 10, 11, 12, 13, and Oe(a) alleles were noted to be monomorphic only. HPA-3a/3b alleles had frequencies of 0.595/0.405, 0.505/0.495, 0.507/0.493, 0.530/0.470, while Gov(a)/Gov(b) of 0.462/0.538, 0.450/0.550, 0.463/0.537, 0.520/0.480 among Taiwanese, Indonesians, Thais and Filipinos respectively. The prevalence rates of HPA-1 to 13 in this study were also consistent with other previous reports using different methods. The alloimmunization due to Gov and HPA-3 antigens need to be emphasized in these populations.
關聯:	INTERNATIONAL JOURNAL OF ONCOLOGY 23(4):1001-1007
显示于类别:	[台中附設醫院] 期刊論文

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