Comparing the relationship of Taxol-based chemotherapy response with P-glycoprotein and lung resistance-related protein expression in non-small cell lung cancer

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Title:	Comparing the relationship of Taxol-based chemotherapy response with P-glycoprotein and lung resistance-related protein expression in non-small cell lung cancer
Authors:	Chiou, JF;Liang, JA;Hsu, WH;Wang, JJ;Ho, ST;Kao, A
Contributors:	附設醫院醫研部;China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan;Taipei Med Univ Hosp, Ctr Canc, Taipei, Taiwan;Taipei Med Univ Hosp, Dept Radiat Oncol, Taipei, Taiwan;China Med Univ Hosp, Dept Radiat Therapy & Oncol, Taichung 404, Taiwan;China Med Univ Hosp, Dept Internal Med, Div Pulm Crit Care Med, Taichung 404, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Tri Serv Gen Hosp, Dept Anesthesiol, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:57:30 (UTC+8)
Publisher:	SPRINGER-VERLAG
Abstract:	This study evaluated the effects of fluticasone propionate inhalation therapy on lung ventilation and alveolar permeability by quantitative Tc-99m DTPA radioaerosol inhalation lung scintigraphy in 15 children with asthma. Lung ventilation was evaluated as the distribution percentage (D%) of Tc-99m DTPA radioaerosols in the central, intermediate and peripheral regions of the right lung. Alveolar permeability was measured by the rate of Tc-99m DTPA radioaerosol clearance curve from the peripheral alveoli of the right lung and represented as slope. The D% and slopes were calculated before and after one-week inhalation therapy (100 mug fluticasone propionate two times daily for one-week) to evaluate the effects of inhalation therapy on lung ventilation and alveolar permeability. The preliminary results revealed statistically significantly improved lung ventilation but no significant change of alveolar permeability in the right lung after one-week fluticasone propionate inhalation therapy in children with asthma. We suggest that the widely available and noninvasive Tc-99m DTPA radioaerosol inhalation lung scintigraphy can simultaneously evaluate lung ventilation and alveolar permeability in one study and should contribute to any disorder involving both alveoli and airways.
Relation:	LUNG 181(5):267-273
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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