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資料載入中.....
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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30542
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| 題名: | THE ROLE OF THE AUTONOMIC NERVOUS-SYSTEM IN CHEMICALLY-INDUCED LIVER-DAMAGE AND REPAIR - USING THE ESSENTIAL HYPERTENSIVE ANIMAL-MODEL (SHR) |
| 作者: | HSU, CT |
| 貢獻者: | 醫學院醫學系病理學科;HSU, CT, CHINA MED COLL,SCH MED,DEPT PATHOL,91 HSUEH SHIH RD,TAICHUNG,TAIWAN |
| 日期: | 1995 |
| 上傳時間: | 2010-09-24 14:57:24 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | In the present study, we extracted Angelica pubescens (AP) with various solvents in order to find the bioactive constituents that demonstrated analgesic and anti-inflammatory effects. The results were obtained as follows: (1) Methanol-, chloroform-, and ethyl acetate-extracts effectively reduced the pain that was induced by 1% acetic acid and a hot plate. (2) Methanol-, chloroform-, and ethyl acetate-extracts reduced the edema that was induced by 3% formalin or 1.5% carrageenan. (3) Sixteen compounds have been isolated and identified from the roots of AP. Among these compounds, columbianadin, columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated anti-inflammatory and analgesic activities at 10 mg/kg. However, only osthole and xanthotoxin revealed anti-inflammatory activity. Isoimperatorin only demonstrated an analgesic effect. These results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central. nervous system. |
| 關聯: | JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM 51(2):135-142 |
| 顯示於類別: | [醫學系] 期刊論文
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