Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells

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Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30527

Title:	Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells
Authors:	Deng, HB;Parekh, HK;Chow, KC;Simpkins, H
Contributors:	附設醫院醫研部;Temple Univ, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19140 USA;Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:57:03 (UTC+8)
Publisher:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Abstract:	The Southeast Asia type deletion of alpha-thalassemia-1 (--(SEA)) is the most common type of alpha-thalassemia-1 in Taiwan. There are 2 less common types, Filipino type (--(FIL)) and Thai type (--(THAI)). In the current study, we screened 754 cases of a-thalassemia-1 in Southern Taiwan using a polymerase chain reaction (PCR)-based method. Our results show that the prevalence of the (--(SEA)) type is 90.6%. followed by the (--(FIL)) type (8.6%), the (--(THAI)) type (0.5%). and the (-alpha(3.7)/-alpha(3.7)) type (0.3%). We also analyzed the genotypes of 96 patients with hemoglobin (Hb) H disease and 48 cases of hydrops fetalis with Hb Bart's. The frequencies of the genotypes of the alpha-thalassemia-1 allele in Hb H disease are in accordance with the results of analyses of alpha-thalassemia-1 cases. The alpha-thalassemia-2 allele includes -alpha(3.7), -alpha(4.2), -alpha(G), alpha(CS)alpha, and alpha(OS)alpha. Forty-one cases, 6 cases, and 1 case of hydrops fetalis with Hb Bart's were caused by --(SEA)/--(SEA), --(SEA)/--(FIL), and --(SEA)/--(THAI), respectively. The genotypes and frequencies of alpha-thalassemia in this study are different from those in previous studies in Taiwan and Hong Kong. These differences may be attributed to the diverse genetic origin among different ethnic groups and the extensive inclusion of the (--(FIL)) and (--(THAI)) alpha-thalassemia-1 types. (C) 2002 The Japanese Society of Hematology.
Relation:	JOURNAL OF BIOLOGICAL CHEMISTRY 277(17):15035-15043
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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