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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30514
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| 題名: | Comparative study of reference points by dosimetric analyses for late complications after uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer |
| 作者: | Chen, SW;Liang, JA;Yeh, LS;Yang, SN;Shiau, AC;Lin, FJ |
| 貢獻者: | 醫學院醫學系放射腫瘤學科;China Med Univ, Sch Med, Dept Radiat Therapy, Taichung, Taiwan;China Med Univ, Sch Med, Dept Oncol, Taichung, Taiwan;China Med Univ, Sch Med, Dept Obstet & Gynecol, Taichung, Taiwan;Natl Taiwan Univ, Sch Med, Taipei, Taiwan;Shin Kong Mem Hosp, Dept Radiat Therapy & Oncol, Taipei, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 14:56:50 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide. Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxification function and increase the susceptibility to endometriosis. We aimed to investigate if these polymorphisms are useful markers for predicting endometriosis susceptibility. Women were divided into two groups: (i) endometriosis (n=150); (ii) non-endometriosis (n=159). Polymorphisms for GSTM1 and MPO were amplified by polymerase chain reaction and detected by electrophoresis after restriction digestion. The relative frequencies of the GSTM1*wild (+/+,+/0)/null (0/0) genotypes and MPO-463*G/A gene polymorphisms between both groups were compared. The distribution of GSTM1 polymorphisms was significantly different between the two groups. Proportions of GSTM1*wild/null alleles in both groups were: (i) 36.7/63.3%; (ii) 95/5% (P=0.001). In contrast, MPO-463 genotypes were not significantly different between the two groups. Proportions of MPO*A homozygote/heterozygote/G homozygote in both groups were: (i) 2.7/17.4/79.9% and (ii) 1.9/17/81.1% (P> 0.05). We conclude that the GSTM1*null genotype is associated with a higher risk of endometriosis development. MPO-463*G/A gene polymorphism is not related to the susceptibility of endometriosis. |
| 關聯: | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 60(2):663-671 |
| 顯示於類別: | [醫學系] 期刊論文
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