Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression

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题名:	Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression
作者:	Wu, HS;Liu, YC;Kao, A;Wang, JJ;Ho, ST
贡献者:	附設醫院醫研部;Show Chwan Mem Hosp, Dept Surg, Changhua 50005, Taiwan;Triserv Gen Hosp, Dept Surg, Taichung, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan
日期:	2002
上传时间:	2010-09-24 14:56:43 (UTC+8)
出版者:	MOSBY, INC
摘要:	Background We carried out a study to predict the prognosis of acute hepatic failure in patients with chronic hepatitis B. Methods. We studied 25 consecutive patients with severe acute hepatitis. Severe acute hepatitis was defined as the development of acute hepatitis with a total serum bilirubin level of more than 15 mg/dl, prolonged prothrombin time (PT) of more than 5 s, and hepatic encephalopathy (HE). All patients were assessed for King's criteria. Positivity for King's criteria was defined as PT more than 100s, or any three of the following: (age < 10 years or > 40 years; cryptogenic or drug-induced hepatitis; jaundice for more than 7 days before the onset of HE; PT > 50s; and serum bilirubin > 17.5 mg/dl). All but I patient had serial serum alphafetoprotein (AFP) levels measured every 1-2 weeks. Results. Eleven of 17 patients who died during the study met the King's criteria, whereas none of the surviving patients met the criteria. The sensitivity was 64.7% and the specificity, 100% for King's criteria in predicting a poor prognosis. In 16 of the 17 deceased patients, the AFP levels were reduced while their jaundice increased (sensitivity, 94.1%; specificity, 87.5%). All 17 deceased patients met the King's criteria and/or had reduced AFP levels while their jaundice increased (sensitivity, 100%; specificity, 87.5%). Conclusions. Our observations suggest that the combined use of follow-up AFP levels and King's criteria is helpful in predicting the poor prognosis of severe acute hepatitis superimposed on chronic hepatitis B.
關聯:	SURGERY 132(3):456-460
显示于类别:	[台中附設醫院] 期刊論文

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