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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30499
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| 題名: | The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas |
| 作者: | Huang, MJ;Yeh, KT;Shih, HC;Wang, YF;Lin, TH;Chang, JY;Shih, MC;Chang, JG |
| 貢獻者: | 附設醫院醫研部;China Med Coll Hosp, Dept Mol Med, Taichung, Taiwan;Mackay Mem Hosp, Dept Internal Med, Hematooncol Sect, Taipei, Taiwan;Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:56:31 (UTC+8) |
| 出版者: | PROFESSOR D A SPANDIDOS |
| 摘要: | The estrogen-signaling pathway plays an important role in the pathophysiology of breast cancer, and the sulfoC transferase 1A (SULT1A) family has been found to be both downstream targets of tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methods to determine SULT1A2 polymorph isms in 230 Taiwanese breast cancer patients. The results showed that the frequencies of SULT1A2*1 and SULT1A2*2 occurring were 94.8% and 5.2%, respectively. No SULT1A2*3 allele was found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% for SULT1A2*1 and SULT1A2*2, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patients were not statistically significant (p = 0.398). However, the SULT1A2*2 allele seems to influence the age of onset among early-onset breast cancer patients (p = 0.021, OR = 2.74, 95% CI = 1.13-6.65). |
| 關聯: | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(5):551-554 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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