The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas

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Title:	The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas
Authors:	Huang, MJ;Yeh, KT;Shih, HC;Wang, YF;Lin, TH;Chang, JY;Shih, MC;Chang, JG
Contributors:	附設醫院醫研部;China Med Coll Hosp, Dept Mol Med, Taichung, Taiwan;Mackay Mem Hosp, Dept Internal Med, Hematooncol Sect, Taipei, Taiwan;Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:56:30 (UTC+8)
Publisher:	PROFESSOR D A SPANDIDOS
Abstract:	The estrogen-signaling pathway plays an important role in the pathophysiology of breast cancer, and the sulfoC transferase 1A (SULT1A) family has been found to be both downstream targets of tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methods to determine SULT1A2 polymorph isms in 230 Taiwanese breast cancer patients. The results showed that the frequencies of SULT1A21 and SULT1A22 occurring were 94.8% and 5.2%, respectively. No SULT1A23 allele was found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% for SULT1A21 and SULT1A22, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patients were not statistically significant (p = 0.398). However, the SULT1A22 allele seems to influence the age of onset among early-onset breast cancer patients (p = 0.021, OR = 2.74, 95% CI = 1.13-6.65).
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(5):551-554
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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