The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30483

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题名:	The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma
作者:	Yeh, KT;Shih, MC;Lin, TH;Chen, JC;Chang, JY;Kao, CF;Lin, KL;Chang, JG
贡献者:	附設醫院醫研部;China Med Coll Hosp, Dept Mol Med, Taichung, Taiwan;China Med Coll Hosp, Dept Lab Med, Taichung, Taiwan;Changhua Christian Hosp, Dept Pathol, Changhua, Peoples R China;Chung Shan Med Univ, Sch Med Technol, Taichung, Taiwan
日期:	2002
上传时间:	2010-09-24 14:56:14 (UTC+8)
出版者:	INT INST ANTICANCER RESEARCH
摘要:	Background: Boron neutron capture therapy (BNCT) is a form of radiation therapy and has been proposed for the treatment of some malignancies with encouraging results. However, none of them has ever been applied to liver malignancy. The purpose of this study was to evaluate the potential of boron-lipiodol (B-lipiodol) for the treatment of VX2 liver tumor via BNCT Materials and Methods: Twelve New Zealand rabbits were randomly separated into two groups: lipiodol and boron-lipiodol groups. The rabbits were anesthetized, a midline incision was made and the left lobe of the liver was injected with 0.1 ml of VX2 tumor cells. After the tumor reached 2-3 cm in diameter, the rabbits were anesthetized and 0.5 ml of boron-lipiodol was injected into the hepatic artery via an angiocatheter. Liver function tests and renal function tests were performed before, at 12 hours, 24 hours, 48 hours and 7 days after injection of drugs in both groups. The concentration of boron in various tissues was determined on the 7th day after injection. Results: Liver function was abnormal at 12 hours after injection, and then gradually returned to normal at 7 days, indicative of acute temporary hepatic damage. As for the renal function, no significant change was noted in either group. The boron level was 49.7 ppm in tumor and 631 ppm in the healthy liver 7 days after injection of B-lipiodol. The ratio of boron concentrations between the tumor and the normal liver tissue was 7.87 As for blood and other organs including spleen, heart and kidney, the concentration of boron was low. In the lipiodol group, the boron concentrations in tumor and various organs were low. Conclusion: The high concentration of boron after intra-arterial injection of B-lipiodol can be used for neutron capture therapy. B-lipiodol has potential for the treatment of liver malignancy.
關聯:	ANTICANCER RESEARCH 22(6C):3971-3975
显示于类别:	[台中附設醫院] 期刊論文

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