Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer

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Title:	Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer
Authors:	Hsu, NY;Ho, HC;Chow, KC;Lin, TY;Shih, CS;Wang, LS;Tsai, CM
Contributors:	附設醫院醫研部;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Div Chest Surg, Dept Surg, Taichung 404, Taiwan;China Med Coll Hosp, Dept Pathol, Taichung 404, Taiwan;China Med Coll, Sch Med, Taichung 404, Taiwan;Vet Gen Hosp, Dept Chest, Sect Thorac Oncol, Taipei 112, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:56:11 (UTC+8)
Publisher:	AMER ASSOC CANCER RESEARCH
Abstract:	Epstein-Barr virus (EBV) has been linked to carcinomas of several body sites, especially of the nasopharynx, salivary gland, lung, and stomach. We present five cases of lymphoepithelioma-like cholangiocarcinoma, including one that had been previously reported. Two patients were men and three were women. Their ages ranged from 42 to 66 years. Histologically, all five tumors were composed of variable proportions of undifferentiated epithelial cells and glandular components in a lymphocyte-rich stroma. EBV was detected in all five tumors by in situ hybridization for EBER-1 in both lymphoepithelioma-like carcinoma (LELC) and glandular parts, but not in 36 cases of cholangiocarcinoma without the LELC component. Taken together, these observations indicate that lymphoepithelioma-like cholangiocarcinoma, is strongly linked to EBV. The LELC type of cholangiocarcinoma, like LELC of other body sites, may be more common in areas with endemic EBV infection.
Relation:	CANCER RESEARCH 61(6):2727-2731
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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