Hb Manitoba in a Taiwanese family: A C -> A substitution at codon 102 of the alpha 2-globin gene

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30463

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题名:	Hb Manitoba in a Taiwanese family: A C -> A substitution at codon 102 of the alpha 2-globin gene
作者:	Chang, JG;Shih, MC;Liu, SC;Chan, WL;Peng, CT
贡献者:	附設醫院醫研部;China Med Coll Hosp, Dept Lab Med, Taichung, Taiwan
日期:	2001
上传时间:	2010-09-24 14:55:52 (UTC+8)
出版者:	MARCEL DEKKER INC
摘要:	Exposure to lead has been shown to have a deleterious effect on the immune system. However, the findings of previous studies have been inconsistent. This may have been due to the increased susceptibility to intracellular pathogens and increased polyclonal and antigen-specific responses on exposure to lead. The objective of the current study was to evaluate the immune function of long-term workers with lead in a battery manufacturing plant. Junior high school teachers were used as a control group. Our results showed that the percentage of monocytes was significantly higher among lead workers than in the control group, but T8 cell levels were lower. The T4/T8 ratio was significantly higher among lead workers (1.42) than in the control group (1.18). After adjustment for age, gender and disease using multiple linear regression models, the percentage of B-cells and number of lymphocytes, monocytes and granulocytes were all significantly decreased among lead workers compared with the control group. Our findings showed that lead caused a marked immunotoxic and immunosuppressive effect among long-term lead workers.
關聯:	HEMOGLOBIN 25(4):437-439
显示于类别:	[台中附設醫院] 期刊論文

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