Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese children

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30441

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题名:	Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese children
作者:	Lee, YJ;Huang, FY;Lo, FS;Wang, WC;Hsu, CH;Kao, HA;Yang, TY;Chang, JG
贡献者:	附設醫院醫研部;China Med Coll Hosp, Dept Med Res, Div Mol Med, Taichung, Taiwan;Mackay Mem Hosp, Dept Paediat, Taipei, Taiwan;Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan;Taipei Med Coll, Dept Paediat, Taipei, Taiwan;Chang Gung Childrens Hosp, Dept Med, Div Endocrinol, Tao Yuan, Taiwan
日期:	2000
上传时间:	2010-09-24 14:55:26 (UTC+8)
出版者:	BLACKWELL SCIENCE LTD
摘要:	Loss of heterozygosity of chromosome 10q has been reported in hepatoma. Areas,with a high rate of loss of genetic material could harbor putative turner suppressor genes. PTEN/MMAC1, a candidate tumor suppressor gene located at chromosome 10q23.3, has recently been identified and found to be homozygously deleted or mutated in several different types of human tumors. To determine whether the PTEN/ MMAC1 gene is a target of 10q loss of heterozygosity in hepatoma, we examined 42 primary hepatomas for mutations in PTEN/MMAC1 by using nested reverse transcriptase polymerase chain reaction (RT-PCR) of the RNA and single-stranded conformation polymorphism (SSCP) analysis of all genomic exons. Although 2 of 42 hepatoma tissues had aberrant transcripts, 5 matched noncancerous liver tissues also had aberrant transcripts. Southern blot analysis of the entire genomic DNA revealed no genomic change. Therefore, like the TSG101 or FHIT gene, aberrant transcripts of PTEN/MMAC1 using the nested RT-PCR method were a common phenomenon for both cancerous and noncancerous liver tissues, which may nor be related to oncogenesis. None of the 42 cases had small deletions, point mutations, or insertions. Our results suggest that the PTEN/MMAC1 gene may not play a role in the pathogenesis of hepatoma.
關聯:	CLINICAL ENDOCRINOLOGY 52(2):153-157
显示于类别:	[台中附設醫院] 期刊論文

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