Temporally shifted hemodynamic response model helps to extract acupuncture-induced functional magnetic resonance imaging blood oxygenation-level dependent activities

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Title:	Temporally shifted hemodynamic response model helps to extract acupuncture-induced functional magnetic resonance imaging blood oxygenation-level dependent activities
Authors:	何宗融(Tsung-Jung Ho);段正仁(Jeng-Ren Duann);陳君明(Chun-Ming Chen);陳中和(Jeon-Hor Chen);沈戊忠(Wu-Chung Shen);呂東武(Tung-Wu Lu);廖俊睿(Jan-Ray Liao);林仁彬(Zen-Pin Lin);邵國寧(Kuo-Ning Shaw);林昭庚(Jaung-Geng Lin)*
Contributors:	中醫學院中醫學系學士班中醫外傷學科;北港醫院中醫部
Date:	2009-04
Issue Date:	2009-08-20 17:58:43 (UTC+8)
Abstract:	BACKGROUND: The onsets of needling sensation introduced by acupuncture stimulus can vary widely from subject to subject. This should be explicitly accounted for by the model blood oxygenation-level dependent (BOLD) time course used in general linear model (GLM) analysis to obtain more consistent across-subject group results. However, in standard GLM analysis, the model BOLD time course obtained by convolving a canonical hemodynamic response function with an experimental paradigm time course is assumed identical across subjects. Although some added-on properties to the model BOLD time course, such as temporal and dispersion derivatives, may be used to account for different BOLD response onsets, they can only account for the BOLD onset deviations to the extent of less than one repetition time (TR). METHODS: In this study, we explicitly manipulated the onsets of model BOLD time course by shifting it with -2, -1, or 1 TR and used these temporally shifted BOLD model to analyze the functional magnetic resonance imaging (fMRI) data obtained from three acupuncture fMRI experiments with GLM analysis. One involved acupuncture stimulus on left ST42 acupoint and the other two on left GB40 and left BL64 acupoints. RESULTS: The model BOLD time course with temporal shifts, in addition to temporal and dispersion derivatives, could result in better statistical power of the data analysis in terms of the average correlation coefficients between the used BOLD models and extracted BOLD responses from individual subject data and the T-values of the activation clusters in the grouped random effects. CONCLUSIONS: The GLM analysis with ordinary BOLD model failed to catch the large variability of the onsets of the BOLD responses associated with the acupuncture needling sensation. Shifts in time with more than a TR on model BOLD time course might be required to better extract the acupuncture stimulus-induced BOLD activities from individual fMRI data.
Relation:	CHINESE MEDICAL JOURNAL 122(7):823~829
Appears in Collections:	[School of Chinese Medicine] Journal articles

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