Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan

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Title:	Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan
Authors:	Chang, NW;Chen, DR;Wu, CT;Aouizerat, BE;Chen, FN;Hung, SJ;Wang, SH;Wei, MF;Chang, CS
Contributors:	醫學院醫學系生化學科;China Med Univ, Coll Med, Dept Biochem, Taichung 404, Taiwan;Changhua Christian Hosp, Dept Surg, Taipei, Taiwan;Feng Yuan Hosp, Execut Yuan, Dept Hlth, Taichung, Taiwan;Univ Calif San Francisco, Dept Physiol Nursing, San Francisco, CA 94143 USA;China Med Univ, Dept Social Med, Taichung, Taiwan;China Med Univ Hosp, Dept Surg, Taichung, Taiwan;Chinese Blood Serv Fdn Taichung Blood Ctr, Taichung, Taiwan;Changhua Christian Hosp, Dept Med Oncol, Taipei, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:55:15 (UTC+8)
Publisher:	SPRINGER
Abstract:	Background. Many infectious agents have been implicated as an etiology to develop Kawasaki disease (KD). In Taiwan, studies on the relationship between Yersinia and KD have not been reported. Methods. We measured sera for anti-Yersinia antibodies by using enzyme immunoassay (EIA) in 31 patients with KD and 60 healthy children (HC). Yersinia strains included Y. pseudotuberculosis I, II, III, IV, V, VI and Y. enterocolitica O3, O8 and O9. Results. Data of 31 patients with KD showed that for the I-G antibody, serum anti-Y. pseudotuberculosis II, III, Y O8 and O9 antibody were significantly higher when compared to the HC. Except for Y. pseudotuberculosis IV, all other Yersinia strains of either IgA or IgM antibodies increased significantly in patients with KD vs. the HC. If we compared the number of patients who had significant elevation of OD and those of HC, we found IgA anti-Yersinia antibodies (PST I, PST II, O3, O8, O9), I-M (PST VI, O8) and I-G (PST II, O8, O9) were significantly elevated in KD patients than in HC. A significant relationship was present between KD with myocarditis and increased anti-Yersinia antibody titer. Conclusions. The findings in this study suggest that preceding Yersinia infection may play a role in the pathogenesis of KD. Further study of the relationship between KD with myocarditis and increased anti-Yersinia antibody is needed. (c) 2005 IMSS. Published by Elsevier Inc.
Relation:	BREAST CANCER RESEARCH AND TREATMENT 90(3):257-261
Appears in Collections:	[School of Medicine] Journal articles

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