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http://ir.cmu.edu.tw/ir/handle/310903500/30424
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| 題名: | Nitric oxide induces prion protein via MEK and p38 MAPK signaling |
| 作者: | Wang, VC;Chuang, TC;Hsu, YD;Chou, WY;Kao, MC |
| 貢獻者: | 醫學院醫學系生化學科;Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan;China Med Univ, Coll Med, Dept Biochem, Taichung, Taiwan;Tri Serv Gen Hosp, Dept Neurol, Taipei, Taiwan;Tamkang Univ, Dept Chem, Taipei, Taiwan;Natl Def Univ, Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan;Cardinal Tien Hosp, Dept Neurol, Taipei, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:55:09 (UTC+8) |
| 出版者: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 摘要: | It has been reported that (-)Menthol can inhibit the growth of rat liver epithelial tumor cells and is a potent chemopreventive agent. The purpose of the present experiment was to examine and identify cellular processes leading to cell death which are affected by (-)Menthol in human gastric SNU-5 cancer cells.. Cell death (cytotoxicity) was examined and analyzed by trypan blue stain and flow cytometric methods. It was shown that (-)Menthol inhibited the proliferation of the cells in a dose- and time-dependent manner, inhibited topoisomerase I, II alpha and II beta, but promoted the levels of NF-kappa B gene expression based on the Western blot and polymerase chain reaction (PCR) and cDNA microarray methods. These data suggest that (-)Menthol may induce cytotoxicity through inhibiting gene expression of topoisomerase I, II alpha a and II beta and promoting the gene expression of NF-kappa B in SNU-5 cells. |
| 關聯: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 333(1):95-100 |
| 顯示於類別: | [醫學系] 期刊論文
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