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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30413
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| 題名: | A novel loss-of-function deletion in sodium/iodide symporter gene in follicular thyroid adenoma |
| 作者: | Liang, JA;Chen, CP;Huang, SJ;Ho, TY;Hsiang, CY;Ding, HJ;Wu, SL |
| 貢獻者: | 醫學院醫學系生化學科;China Med Univ, Dept Biochem, Taichung 404, Taiwan;China Med Univ, Dept Microbiol, Taichung 404, Taiwan;China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan;China Med Univ Hosp, Dept Med Res, Taichung, Taiwan;China Med Univ Hosp, Dept Radiat Therapy, Taichung, Taiwan;China Med Univ Hosp, Dept Oncol, Taichung, Taiwan;I Shou Univ, Dept Radiol Technol, Kaohsiung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:54:56 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | Human papillomavirus (HPV) infection is a high-risk factor for cervical intraepithelial neoplasm (CIN) but the association between the quantitative HPV DNA load and the severity of CIN remains controversial. We conducted a community study to investigate the correlation between the two. Potential study subjects were selected through Pap smear screening in Kaohsiung County, Taiwan. Ninety-one subjects with either their first case of inflammation or >= CIN2 by biopsy confirmation were assigned to a case group; 175 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group. Cervical HPV load was detected with Hybrid Capture II assay for high-risk HPV infection, with nested PCR for high- and low-risk HPV infection, and with type-specific PCR for HPV type 16 (HPV-16). Individuals with positive high-risk HPV infection had an increased risk of developing CIN. Compared with HPV-negative subjects, the odds ratios were 32.2 [95% confidence interval (95% CI), 10.4-99.5] for subjects with CIN1, 37.2 (95% Cl, 7.4-187.6) for subjects with CIN2, and 68.3 (95% Cl, 14.13-28.5) for subjects with > CIN3 after adjusting for other confounding factors. The similar trend was also found among the HPV-16-negative individuals. In addition, high-risk HPV DNA load levels were highly correlated with the different grades of CINs in the overall population (Spearman's correlation coefficient r = 0.67, P < 0.0001, n = 266) and the HPV-16-negative population (Spearman's correlation coefficient r = 0.58, P < 0.0001, n = 234). We concluded that high-risk HPV infection, irrespective of HPV-16 infection, was highly and positively associated with the development of CIN. |
| 關聯: | CANCER LETTERS 230(1):65-71 |
| 顯示於類別: | [醫學系] 期刊論文
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