Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38

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Title:	Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38
Authors:	Yang, JS;Hour, MJ;Kuo, SC;Huang, LJ;Lee, MR
Contributors:	醫學院醫學系生化學科;China Med Univ, Sch Med, Dept Biochem, Taichung 404, Taiwan;China Med Univ, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan;China Med Univ, Sch Pharm, Taichung 404, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:54:45 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	The aim of this study was (1) to investigate the correlation between external exposure to N,N-dimethylformamide (DAY) and urinary excretion of DMF and N-methylformamide; (2) to assess whether the correspondence between the current occupational exposure limit setting and recommended urinary biological exposure index is substantial; and (3) to evaluate whether coexposure to toluene, methyl ethyl ketone, and ethyl acetate has an effect on urinary excretion of DAY and N-methylformamide (MMF). Urinary DAY and NAY were significantly correlated (P < 0.01) with one another and also significantly correlated with airborne DMF (P < 0.01) over the range of 1.55 to 152.8 mg/m(3). Urinary DAY can be considered a complementary marker for short-term exposure. Urinary concentration of NAY, and DMF, corresponding to the 8-hour exposure to airborne DAY at 30 mg/m(3) was estimated to 38.4 mg/L or 39.4 mg/g creatinine for NW and to 0.92 mg/L or 0.96 mg/g creatinine for DMF.
Relation:	ANTICANCER RESEARCH 24(3A):1769-1778
Appears in Collections:	[School of Medicine] Journal articles

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