A phenylacetate derivative, SCK6, inhibits cell proliferation via G(1) cell cycle arrest and apoptosis

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Title:	A phenylacetate derivative, SCK6, inhibits cell proliferation via G(1) cell cycle arrest and apoptosis
Authors:	Chan, HC;Kuo, SC;Huang, LJ;Liu, CH;Hsu, SL
Contributors:	醫學院醫學系生化學科;China Med Coll, Dept Biochem, Taichung, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Chung Shan Med Univ, Sch Med, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:54:42 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	We determined the complete nucleotide sequence of the YL strain of Japanese encephalitis virus and its amino acid sequence was deduced. Our results displayed that the genome of YL strain contained a single open reading frame of 10,296 nucleotides (nts) which was flanked by untranslated region (UTR) containing 95 bases at the 5'-end and 586 bases at the 3'-end, respectively. Comparison of sequences showed that the overall amino acid sequence and 3' UTR of YL were similar to those of the virulent strain JaGAr01. However, some significant amino acid differences of viral envelope (E) protein were observed between YL and JaGAr01; the amino acid sequence of E protein in YL strain possessed RGG((387-389)) tripeptide instead of RGD(387-389) in JaGAr01 and in other strains; and another amino acid is K-(138) in YL, not E-(138) found in others. These differences suggested that the YL strain impairs in viral attachment to the cell surface and loses neuroinvasiveness, and therefore this strain was used as a live attenuated vaccine.
Relation:	EUROPEAN JOURNAL OF PHARMACOLOGY 467(1月3日):31-39
Appears in Collections:	[School of Medicine] Journal articles

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