4-fluoro-N-butylphenylacetamide: a synthetic phenylacetate derivative that upregulates Bcl-X-s, activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells

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Title:	4-fluoro-N-butylphenylacetamide: a synthetic phenylacetate derivative that upregulates Bcl-X-s, activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells
Authors:	Chan, HC;Kuo, SC;Liu, SC;Liu, CH;Hsu, SL
Contributors:	醫學院醫學系生化學科;Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan;China Med Coll, Dept Biochem, Taichung, Taiwan;China Med Coll, Grad Inst Pharmacuet Chem, Taichung, Taiwan;Chung Shan Med Univ, Sch Med, Taichung, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:54:29 (UTC+8)
Publisher:	ELSEVIER SCI IRELAND LTD
Abstract:	The aim of our study was to compare the usefulness of technetium-99m tetrofosmin (Tc-TF) mammoscintigraphy and ultrasonography for detecting breast cancer in mammographically dense breasts. This study included 32 female Taiwanese patients with indeterminate mammographic probability of malignancy due to mammographically dense breasts. Both Tc-TF mammoscintigraphy and ultrasonography were performed on each patient. Then, all of the 32 breast masses underwent biopsies or operations to obtain final pathological diagnoses. Based on the final pathological diagnoses, 24 women had breast cancer and eight had benign breast tumors among the 32 patients. Twenty cancers and one benign tumor had positive Tc-TF mammoscintigraphic findings. The sensitivity, specificity, and accuracy were 83, 88, and 84%, respectively. Twenty-two cancers and five benign tumors had positive ultrasonographic findings. The sensitivity, specificity, and accuracy were 92, 38, and 78%, respectively. To detect breast cancer in patients with nondiagnostic mammograms because of mammographically dense breasts, ultrasonography with its higher sensitivity is more suitable for screening breast masses. However, due to its higher specificity, Tc-TF mammoscintigraphy is useful to confirm the ultrasonographic findings.
Relation:	CANCER LETTERS 186(2):211-221
Appears in Collections:	[School of Medicine] Journal articles

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