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| 題名: | Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-ornithine aminomutase from Clostridium sticklandii |
| 作者: | Chen, HP;Wu, SH;Lin, YL;Chen, CM;Tsay, SS |
| 貢獻者: | 醫學院醫學系生化學科;China Med Coll, Dept Biochem, Taichung 404, Taiwan;Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan;Natl Taiwan Univ, Dept Bot, Taipei 106, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:54:20 (UTC+8) |
| 出版者: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 摘要: | The initiation of focal atrial tachycardia (AT) from the superior vena cava (SVC) remains unclear, In 3 patients (2 females, 1 male aged 57, 66 and 50 years, respectively) with focal AT arising from different parts of the SVC, the AT occurred spontaneously, rather than being induced by electrical stimulation. The cycle length of the tachycardia was highly variable, ranging between 190 and 300 ms in patient 1,180 and 320 ms in patient 2, and 200 and 300 ms in patient 3. The clinical or associated arrhythmias were atrial fibrillation (AF) (patients 1, 3) and atrial flutter (AFL) (patients 2. 3). A presumed SVC potential that was earlier than the activation of all the other mapping sites was recorded during AT at the lower anterior ( 15-mm above the atriocaval junction), the mid-anterior (25-mm above the atriocaval junction) and the lower posterior aspect of the SVC ( 17-mm above the atriocaval junction. Radiofrequency (RF) ablation targeting the SVC focus with the SVC potential promptly eliminated the focal AT in all 3 patients. The coexistent typical AFL was ablated, but the AF was not. The follow-up period was 6, 6, and 3 months, respectively, for each of the patients under no antiarrhythmic medication; there has not been a recurrence of symptomatic palpitation. In conclusion, focal electrical firing in the SVC can initiate AT and this type of focal AT is always associated with AFL or AF. RF ablation guided by the presumed SVC potential is safe and highly effective in eliminating the tachycardia. |
| 關聯: | JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):44744-44750 |
| 顯示於類別: | [醫學系] 期刊論文
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