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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30372
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| 題名: | Purification and properties of ornithine racemase from Clostridium sticklandii |
| 作者: | Chen, HP;Lin, CF;Lee, YJ;Tsay, SS;Wu, SH |
| 貢獻者: | 醫學院醫學系生化學科;China Med Coll, Dept Biochem, Taichung 404, Taiwan;Natl Chung Hsing Univ, Dept Food Sci, Taichung 402, Taiwan;Natl Taiwan Univ, Dept Bot, Taipei 106, Taiwan;Acad Sinica, Inst Biol Chem, Nankang 115, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:54:14 (UTC+8) |
| 出版者: | AMER SOC MICROBIOLOGY |
| 摘要: | The purpose of this study was to retrospectively predict the chemotherapy response to paclitaxel in non-small cell lung cancer (NSCLC) using technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) chest single-photon-emission computed tomography (SPECT) to detect the expression of multidrug-resistance-mediated M-r 170,000 P-glycoprotein, Before chemotherapy with Paclitaxel (Taxol), 30 patients with stage IIIb or TV NSCLC were enrolled in this study. Early chest SPECT 10 min after i.v. injection of Tc-99m MIBI was performed to qualitatively interpret Tc-99m MIBI chest SPECT visually and quantitatively calculate early tumor:normal lung ratios (T:NL) for quick assessment of multidrug-resistant P-glycoprotein expression in NSCLC. On the basis of qualitatively visual interpretation of early Tc-99m MIBI chest SPECT, all of 15 (100%) cases with good response to chemotherapy with Taxol could be detected but 10 (67%) of 15 cases with poor response could not be detected. Early Tc-99m MIBI chest SPECT could correctly predict chemotherapy response in 25 (83%) of 30 of cases. The early T:NL were 3.30 +/- 0.82 for 15 patients with good response and 2.02 +/- 0.19 for 5 patients with poor response. The differences were significant (P < 0.05) by independent Student t tests. However, no significant differences were found for other prognostic factors (age, sex, tumor size, tumor location, stage, and cell type) between good-response and poor-response patients. Early Tc-99m MIBI chest SPECT has the potential to predict chemotherapy response to Paclitaxel. |
| 關聯: | JOURNAL OF BACTERIOLOGY 182(7):2052-2054 |
| 顯示於類別: | [醫學系] 期刊論文
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