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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30367
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| 題名: | Protein structure and gene cloning of Syncephalastrum racemosum nuclease |
| 作者: | Ho, HC;Liao, TH |
| 貢獻者: | 醫學院醫學系生化學科;Natl Taiwan Univ, Coll Med, Inst Biochem, Taipei, Taiwan;China Med Coll, Dept Biochem, Taichung, Taiwan |
| 日期: | 1999 |
| 上傳時間: | 2010-09-24 14:54:07 (UTC+8) |
| 出版者: | PORTLAND PRESS |
| 摘要: | Background: Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are the two primary causes of peptic ulcer disease. How H. pylori and NSAIDs interact and influence the development of ulcer bleeding is still not clear. Methods: A hospital-based, age- and sex-matched case-control study was conducted. Multivariate and stratified analyses were performed for further evaluation of the interaction between H. pylori and NSAIDs. Results: Ninety-seven patients (52 gastric ulcers, 45 duodenal ulcers) and 97 non-ulcer controls were enrolled in the study. H. pylori and NSAIDs were both found to be independent risk factors for ulcer bleeding (H. pylori odds ratio, 2.22; 95% confidence interval (CI), 1.23-4.01; NSAIDs odds ratio, 4.57; 95% CI, 2.50-8.35). There was no synergistic effect. In contrast, a negative interaction was observed in the logistic regression and stratified analysis, although the difference was not significant (H. pylori adjusted odds ratio, 3.47; 95% CI, 1.73-6.95; NSAID adjusted odds ratio, 6.16; 95% CI, 3.14-12.09). Conclusion: H. pylori increases the risk of peptic ulcer bleeding but may play a protective role in NSAID users. |
| 關聯: | BIOCHEMICAL JOURNAL 339():261-267 |
| 顯示於類別: | [醫學系] 期刊論文
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