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http://ir.cmu.edu.tw/ir/handle/310903500/30355
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| 題名: | Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer |
| 作者: | Tseng, TL;Shih, YP;Huang, YC;Wang, CK;Chen, PH;Chang, JG;Yeh, KT;Chen, YMA;Buetow, KH |
| 貢獻者: | 附設醫院檢驗醫學部;NCI, Lab Populat Genet, Ctr Canc Res, Bethesda, MD 20892 USA;Natl Yang Ming Univ, Inst Publ Hlth, Div Prevent Med, Taipei 112, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Internal Med, Taipei 106, Taiwan;Yuans Gen Hosp, Dept Internal Med, Kaohsiung 802, Taiwan;China Med Coll Hosp, Dept Lab Med, Taichung, Taiwan;Changhua Christian Hosp, Dept Pathol, Changhua 500, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:53:53 (UTC+8) |
| 出版者: | AMER ASSOC CANCER RESEARCH |
| 摘要: | The ameliorating effects of LiuWei Dihuang Wang (LDW) after single, one-week or two-week treatment of scopolamine (SCOP)-induced and p-chloroamphetamine (PCA)-induced amnesia by using the passive avoidance task and the facilitatory effects on two-way active avoidance performance in rats were studied. LDW (2 g/kg) after single treatment significantly prolonged the shortened step-through latency induced by SCOP and PCA. Then, SCOP- and PCA-induced amnesia was reversed by 1 and 0.1-1 g/kg LDW with one-week consecutive treatment respectively. For two-week consecutive treatment with LDW, the reversal from SCOP- and PCA-induced amnesia required only 0.01 g/kg. However, the rats treated with LDW only at 0.5, but not 0.01-4.1 g/kg, before or after each training session showed an increasing number of avoidances and a decreasing number of escapes on days 2-5 of learning. LDW at any dose alone did not influence the step-through latency in the training trial produced by non-shock rats, the motor activity and pentobarbital-induced hypnosis in rodents. These results suggest that LDW possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models. |
| 關聯: | CANCER RESEARCH 63(3):647-654 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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